There are many great villains in anime, but here are 22 of the best female villains in the genre. From assassins to witches, these baddies have done something despicable and dangerous onscreen time and again. So without further ado, here are 22 of the best female villains in anime!

  1. Yoko Shimomura as Aoi Aoi is a wicked witch who has been responsible for countless murders and mayhem in anime over the years. She’s a cold-blooded killer who enjoys torturing her victims before killing them. Her evil ways have earned her a place at the top of this list, and she’s one of the most iconic villains in all of anime.
  2. Miki Hoshino as Ayeka Ayeka is an evil sorceress who has been responsible for causing great destruction both on and off screen. She’s a powerful witch who can control fire, ice, and wind – making her one of the most dangerous characters in all of anime. Her evil ways have earned her a place at the top of this list, and she’s one of the most iconic villains in all of anime.
  3. Yūko Kaji as Ruri Ruri is an evil spirit who has been responsible for causing many deaths and destruction throughout history. She’s a powerful being with links to both death and magic – making her one of the most powerful characters in all of anime. Her evil ways have earned her a place at the top of this list, and she’s one of the most iconic villains in all of anime